The N-myc Oncogene: Maximizing its Targets, Regulation, and Therapeutic Potential.

TitleThe N-myc Oncogene: Maximizing its Targets, Regulation, and Therapeutic Potential.
Publication TypeJournal Article
Year of Publication2014
AuthorsBeltran H
JournalMol Cancer Res
Volume12
Issue6
Pagination815-22
Date Published06/2014
Abstract

N-myc (MYCN), a member of the Myc family of basic-helix-loop-helix-zipper (bHLHZ) transcription factors, is a central regulator of many vital cellular processes. As such, N-myc is well recognized for its classic oncogenic activity and association with human neuroblastoma. Amplification and overexpression of N-myc has been described in other tumor types, particularly those of neural origin and neuroendocrine tumors. This review outlines N-myc's contribution to normal development and oncogenic progression. In addition, it highlights relevant transcriptional targets and mechanisms of regulation. Finally, the clinical implications of N-Myc as a biomarker and potential as a target using novel therapeutic approaches are discussed.

URLhttps://www.ncbi.nlm.nih.gov/pubmed/24589438
DOI10.1158/1541-7786.MCR-13-0536