Beltran Lab

The Beltran lab is focused on understanding mechanisms of treatment resistance in advanced prostate cancer through integration of clinical and molecular features of patients combined with preclinical modeling.  We have focused on understanding mechanisms underlying an emerging subclass of androgen-indifferent prostate cancers that develop neuroendocrine features as an adaptive response mechanism upon selective therapeutic pressure of the androgen receptor (AR).  We have used genomics and epigenomics to elucidate the molecular mechanisms driving evolution towards an AR-low state.  We are developing tissue and circulating biomarkers and novel therapeutic strategies for clinical translation.  Our mission is to make discoveries that improve the way we manage and treat patients with advanced prostate cancer.

In addition, as part of the Englander Institute for Precision Medicine and in collaboration with a multidisciplinary team of scientists and clinicians, we are developing genomic and other platforms for biomarker development and clinical application across tumor types. 


PC: Jesse Winter

Read about the Beltran Lab's recent findings in new publications


The Beltran Lab's mission is to characterize the molecular landscape of neuroendocrine prostate cancer and identify new therapeutic targets. 

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Patient Derived Prostate Cancer Organoids to Advance Precision Medicine

Loredana Puca, Ph.D., and a team of scientists from the Beltran Lab and Englander Institute for Precision Medicine at Weill Cornell Medicine, developed tumor organoids that recapitulate neuroendocrine prostate cancer, a rare and aggressive disease.

Prostate Cancer Foundation Announces 2017 PCF Challenge Awards to Accelerate the Development of New Treatments for Advanced Prostate Cancer

WASHINGTON, D.C., October 5, 2017 – The Prostate Cancer Foundation (PCF) today announced awards totaling $7.5 million to fund new 2017 PCF Challenge Awards supporting international, cross-disciplinary teams of investigators conducting pioneering rese

Weill Cornell Medicine Awarded $11.3 Million Prestigious Grant for Prostate Cancer Research