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Biology and evolution of poorly differentiated neuroendocrine tumors.

TitleBiology and evolution of poorly differentiated neuroendocrine tumors.
Publication TypeJournal Article
Year of Publication2017
AuthorsRickman DS, Beltran H, Demichelis F, Rubin MA
JournalNat Med
Volume23
Issue6
Pagination1-10
Date Published2017 Jun 06
ISSN1546-170X
Abstract

Neuroendocrine (NE) cancers are a diverse group of neoplasms typically diagnosed and treated on the basis of their site of origin. This Perspective focuses on advances in our understanding of the tumorigenesis and treatment of poorly differentiated neuroendocrine tumors. Recent evidence from sequencing indicates that, although neuroendocrine tumors can arise de novo, they can also develop as a result of lineage plasticity in response to pressure from targeted therapies. We discuss the shared genomic alterations of these tumors independently of their site of origin, and we explore potential therapeutic strategies on the basis of recent biological findings.

DOI10.1038/nm.4341
Alternate JournalNat. Med.
PubMed ID28586335